Artavis Scott caught a five-yard pass from Nick Schuessler to put Clemson up 30-0 with 1:27 left in the first half.
After Deshaun Watson came off the field after a 13-yard run to convert on third down, Schuessler came in and finished the job.
He had a key 24-yard completion on fourth down to Jordan Leggett.
The drive consisted of 14 plays for 86 yards in 5:03. The Tigers continue the trend of long scoring drives, putting up their third longest of the season.