After the College of Charleston tied the game in the top of the second with two runs, Clemson responded to regain the lead in the bottom half.
Andrew Cox singled and Robert Jolly walked to start the inning. Cox moved to third on a long fly from Greene. Grayson Byrd singled to short to score Cox for a 3-2 lead at the time.
Reed Rohlman doubled, his second of the day, to score Jolly, and then Byrd tried to score on the play but was thrown out at the plate.
The Tigers led 4-2 after two innings of play.