Clemson took a 2-1 lead in the bottom of the first inning when Chase Pinder blasted a shot to left field.
With the count sitting at 2-2, Pinder sent a rocket down the left field line for his second home run of the series. It was the center fielder’s sixth home run of the year.
It also scored Reed Rohlman on the play. The Clemson left fielder reached second base when Louisville left fielder Ryan Summers dropped a routine fly ball.
The Tigers led 2-1 after one inning.