2021 Baseball Schedule |
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| Day | Date | Opponent | Location | Time/Result | Record |
| Fri | 2/19 | Cincinnati | Clemson, SC | 4:00PM | |
| Sat | 2/20 | Cincinnati | Clemson, SC | 3:00PM | |
| Sun | 2/21 | Cincinnati | Clemson, SC | 1:00PM | |
| Fri | 2/26 | South Carolina | Clemson, SC | 4:00PM | |
| Sat | 2/27 | South Carolina % | Greenville, SC | 4:00PM | |
| Sun | 2/28 | South Carolina | Columbia, SC | 1:30PM | |
| Tue | 3/2 | East Tennessee State | Clemson, SC | 4:00PM | |
| Fri | 3/5 | Notre Dame | Clemson, SC | 4:00PM | |
| Sat | 3/6 | Notre Dame | Clemson, SC | 3:00PM | |
| Sun | 3/7 | Notre Dame | Clemson, SC | 1:00PM | |
| Tue | 3/9 | USC Upstate | Clemson, SC | 4:00PM | |
| Fri | 3/4 | North Carolina * | Chapel Hill, NC | 6:00PM | |
| Sat | 3/6 | North Carolina * | Chapel Hill, NC | 2:00PM | |
| Sun | 3/7 | North Carolina * | Chapel Hill, NC | 1:00PM | |
| Tue | 3/16 | Georgia State | Clemson, SC | 6:00PM | |
| Fri | 3/19 | Virginia Tech * | Clemson, SC | 6:00PM | |
| Sat | 3/20 | Virginia Tech * | Clemson, SC | 3:00PM | |
| Sun | 3/21 | Virginia Tech * | Clemson, SC | 1:00PM | |
| Tue | 3/23 | Georgia Southern # | North Augusta, SC | 6:30 PM | |
| Fri | 3/26 | Boston College * | Brighton, Mass | 4:00PM | |
| Sat | 3/27 | Boston College * | Brighton, Mass | 3:00PM | |
| Sun | 3/28 | Boston College * | Brighton, Mass | 1:00PM | |
| Tue | 3/30 | Georgia | Clemson, SC | 6:00PM | |
| Fri | 4/2 | North Carolina State * | Raleigh, NC | 6:30PM | |
| Sat | 4/3 | North Carolina State * | Raleigh, NC | 6:30PM | |
| Sun | 4/4 | North Carolina State * | Raleigh, NC | 1:00PM | |
| Fri | 4/9 | Virginia * | Clemson, SC | 6:00PM | |
| Sat | 4/10 | Virginia * | Clemson, SC | 3:00PM | |
| Sun | 4/11 | Virginia * | Clemson, SC | 1:00PM | |
| Tue | 4/13 | Charleston | Clemson, SC | 6:00PM | |
| Fri | 4/16 | Miami * | Coral Gables, FL | 7:00PM | |
| Sat | 4/17 | Miami * | Coral Gables, FL | 7:00PM | |
| Sun | 4/18 | Miami * | Coral Gables, FL | 1:00PM | |
| Tue | 4/20 | Georgia | Athens, GA | 6:00PM | |
| Fri | 4/23 | Wake Forest * | Clemson, SC | 6:00PM | |
| Sat | 4/24 | Wake Forest * | Clemson, SC | 3:00PM | |
| Sun | 4/25 | Wake Forest * | Clemson, SC | 1:00PM | |
| Fri | 4/30 | Louisville * | Clemson, SC | 6:00PM | |
| Sat | 5/1 | Louisville * | Clemson, SC | 3:00PM | |
| Sun | 5/2 | Louisville * | Clemson, SC | 12:00PM | |
| Wed | 5/5 | USC Upstate | Clemson, SC | 6:00PM | |
| Fri | 5/7 | Georgia Tech * | Atlanta, GA | 6:00PM | |
| Sat | 5/8 | Georgia Tech * | Atlanta, GA | 4:00PM | |
| Sun | 5/9 | Georgia Tech * | Atlanta, GA | 1:00PM | |
| Sat | 5/14 | Florida State * | Tallahassee, FL | 6:00PM | |
| Sat | 5/15 | Florida State * | Tallahassee, FL | 2:00PM | |
| Sun | 5/16 | Florida State * | Tallahassee, FL | 1:00PM | |
| Thu | 5/20 | Duke * | Clemson, SC | 6:00PM | |
| Fri | 5/21 | Duke * | Clemson, SC | 6:00PM | |
| Sat | 5/22 | Duke * | Clemson, SC | 1:00PM | |
| 5/20-25 | ACC Baseball Tournament | TBA | TBA | ||
| * | ACC Regular-Season Game | ||||
| % | Fluor Field, Greenville, SC | ||||
| # | SRP Park, North Augusta, SC | ||||
